Preparation and Palladium Mediated Cross-Coupling Reactions of cis-2,3-Disubstituted 5-Halo-Dihydropyran-4-ones

All articles of this category Treatment of the cis-2,3-disubstituted dihydropyran-4-ones 1 with iodosobenzene diacetate and trimethylsilyl bromide or iodide afforded the α-halo dihydropyran-4-ones 2/3 in 81-93% yield. The α-iodo dihydropyran-4-one 3c was then cross-coupled under palladium(0) catalysis to furnish the α-aryl and α-vinyl dihydropyran-4-ones 4 and 5 in 66% and 76% yield respectively. hypervalent iodine - palladium - cross-coupling - dihydropyran-4-ones