Key result
In dogs, mean lipoprotein-lipase enzyme responses were directly related to the logarithm of the administered heparin dose.
Supports heparin dosing studies in humans; leaves open clinical translation of canine logarithmic response.
Recent evidence suggests an interrelationship between platelets, heparin, and the lipolytic enzyme, lipoprotein-lipase. It seems likely that heparin might influence platelet adherence through its activation of lipoprotein-lipase. The mode of activation of the enzyme by heparin may, therefore, be important clinically. In these experiments the enzyme responses to increasing doses of heparin have been measured in dogs. The mean enzyme responses were found to be directly related to the logarithm of the heparin dose.
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Morris et al. (1971) studied this question. Heparin was evaluated on Lipoprotein-lipase enzyme responses. In dogs, mean lipoprotein-lipase enzyme responses were directly related to the logarithm of the administered heparin dose.