Key result
Protein transporters of fatty acids (fatty acid-binding proteins) play an important role in the development of metabolic inflammation associated with obesity and related diseases.
Highlights the role of fatty acid-binding proteins in metabolic inflammation related to obesity, diabetes, and atherosclerosis.
Answers are grounded in this paper and cite their sources.
May guide novel anti-inflammatory targets in obesity; leaves open clinical translation pending interventional trials.
Obesity, type 2 diabetes mellitus, and atherosclerosis are associated with the development of "metabolic" inflammation. The proinflammatory mechanisms in adipocytes and macrophages are initiated by both extracellular mediators (cytokines, saturated fatty acids) and intracellular processes (endoplasmic reticulum stress, excessive production of free radicals). An important role in the development of "metabolic" inflammation is played by protein transporters of fatty acids ("fatty acid-binding proteins").
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Васюкова et al. (2012) conducted a review in Obesity, type 2 diabetes mellitus, and atherosclerosis. Fatty acid-binding proteins was evaluated. Protein transporters of fatty acids (fatty acid-binding proteins) play an important role in the development of metabolic inflammation associated with obesity and related diseases.
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