Key result
A multidisciplinary approach combining surgical explantation and six weeks of intravenous liposomal amphotericin B successfully treated Candida albicans pacemaker lead endocarditis in a 68-year-old man.
Why the study?
Fungal endocarditis is a rare, life-threatening complication of permanent cardiac pacing with challenging diagnosis due to nonspecific presentation, requiring prompt management.
Case Report (n=1)
No
Highlights the importance of early diagnosis and a combined medical and surgical approach for managing rare fungal pacemaker lead endocarditis.
May support combined surgical-antifungal therapy in rare fungal device endocarditis; leaves open generalizability and optimal regimens.
Fungal endocarditis (FE) is a rare yet potentially life-threatening complication of permanent cardiac pacing, most commonly caused by species of the genera Candida and Aspergillus. The diagnosis is challenging, as the clinical presentation of FE is usually nonspecific and insidious. A high level of clinical suspicion is required, particularly in patients with implantable pacemakers presenting with unexplained fever. Early diagnosis is crucial for effective and prompt management, which generally relies on a combined medical and surgical approach. We report a case of fungal pacemaker lead endocarditis caused by Candida albicans in a 68-year-old man, which was successfully treated with a multidisciplinary approach combining surgical explantation and antifungal therapy.
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Karrati et al. (2025) conducted a case report in Candida albicans Pacemaker Lead Endocarditis (n=1). Surgical explantation and liposomal amphotericin B was evaluated on Clinical recovery and clearance of infection. A multidisciplinary approach combining surgical explantation and six weeks of intravenous liposomal amphotericin B successfully treated Candida albicans pacemaker lead endocarditis in a 68-year-old man.
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