Swinhoeisterols C–F ( 1 – 4 ), four new steroids having a rearranged 6/6/5/7 ring system, were isolated from the Xisha sponge Theonella swinhoei, together with the known analogue swinhoeisterol A ( 5 ). Their structures were determined based on spectroscopic analysis, TDDFT-ECD and optical rotation calculations, and biogenetic correlations. In an in vitro assay, compound 1 showed an inhibitory effect on (h)p300 with an IC 50 value of 8.8 μM, whereas compounds 2 – 4 were not active.
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Li et al. (2018) studied this question.
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