Key result
In patients with colorectal cancer undergoing resection surgery, pathological stage 4 was associated with a significantly increased hazard of local or distant recurrence (AHR 7.62) compared to stage 2.
Why the study?
When multiple outcomes such as recurrence and death occur, classical survival analysis assumptions are violated, requiring competing risks survival analysis to assess risk factors.
Cohort (n=254)
No
Hazard Ratio: 7.62 (95% CI 3.46–16.92)
p-value: p=<0.05
In patients with colorectal cancer undergoing resection, older age, advanced pathological stage, and rectum tumor site are significant independent risk factors for mortality and recurrence.
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May refine postoperative risk stratification in CRC; leaves open whether competing risks models should guide clinical decisions.
Safari et al. (2021) conducted a cohort in Colorectal cancer (n=254). Pathological stage 4 vs. Pathological stage 2 was evaluated on Local/distance recurrence (AHR 7.62, 95% CI 3.46-16.92, p=<0.05). In patients with colorectal cancer undergoing resection surgery, pathological stage 4 was associated with a significantly increased hazard of local or distant recurrence (AHR 7.62) compared to stage 2.
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