Cross-Sectional (n=333)
No
Answers are grounded in this paper and cite their sources.
In heart and kidney transplant candidates, acute HEV infection is absent, but prior exposure is present in nearly 10% and is associated with older age.
BACKGROUND: Acute hepatitis E virus (HEV) infection in solid organ transplant recipients is rare, but can cause severe hepatic and extrahepatic complications. We sought to identify the pretransplant prevalence of HEV infection in heart and kidney candidates and any associated risk factors for infection. MATERIAL AND METHODS: Stored frozen serum from patients undergoing evaluation for transplant was tested for HEV immunoglobulin G (IgG) antibodies and HEV RNA. All patients were seen at Mayo Clinic Hospital, Phoenix, Arizona, with 333 patients evaluated for heart (n = 132) or kidney (n = 201) transplant. HEV IgG antibodies (anti-HEV IgG) were measured by enzyme-linked immunosorbent assay, and HEV RNA by a noncommercial nucleic acid amplification assay. RESULTS: The prevalence of anti-HEV IgG was 11.4% (15/132) for heart transplant candidates and 8.5% (17/201) for kidney transplant candidates, with an overall seroprevalence of 9.6% (32/333). None of the patients tested positive for HEV RNA in the serum. On multivariable analysis, age older than 60 years was associated with HEV infection (adjusted odds ratio, 3.34; 95% CI, 1.54-7.24; P = 0.002). CONCLUSIONS: We conclude that there was no evidence of acute HEV infection in this pretransplant population and that older age seems to be associated with positive anti-HEV IgG.
No takes yet. Share an insight, caveat, or question.
Unzueta et al. (2015) conducted a cross-sectional in Heart and kidney transplant candidates (n=333). Age older than 60 years vs. Age 60 years or younger was evaluated on HEV infection (anti-HEV IgG positivity) (adjusted OR 3.34, 95% CI 1.54-7.24, p=0.002).
Synapse has enriched 10 related papers. Consider them for comparative context: