What question did this study set out to answer?

To evaluate the in vitro inhibitory effects of bromophenol and diarylmethanone derivatives on key metabolic enzymes involved in diabetes and its secondary complications.

November 27, 2018Archiv der Pharmazie

Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes

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Authors

YDYeliz DemirArdahan University PTParham TaslımıBartin University MÖMuhammet Serhat ÖzaslanArdahan University

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Implication

In vitro study demonstrates potent inhibition of metabolic enzymes by bromophenol derivatives, suggesting their potential as multi-target antidiabetic agents.

Key Points

To evaluate the in vitro inhibitory effects of bromophenol and diarylmethanone derivatives on key metabolic enzymes involved in diabetes and its secondary complications.
Assayed synthesized bromophenol derivatives against aldose reductase (AR) to determine Ki inhibition values.
Tested compound inhibitory activity against porcine pancreatic α-amylase and Saccharomyces cerevisiae α-glucosidase.
Compound 1f demonstrated the most potent AR inhibition with a Ki of 0.05 ± 0.01 μM, while compound 1d had the lowest AR inhibition with a Ki of 1.13 ± 0.99 μM.
All tested compounds exhibited strong α-glucosidase inhibition, showing Ki values ranging from 43.62 ± 5.28 to 144.37 ± 16.37 nM.
Tested compounds effectively inhibited α-amylase, producing IC50 values between 9.63 and 91.47 nM.

Cite This Study

Demir et al. (2018) studied this question.

synapsesocial.com/papers/6aa03be229ad9135009b003e https://doi.org/10.1002/ardp.201800263

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Implication

In vitro study demonstrates potent inhibition of metabolic enzymes by bromophenol derivatives, suggesting their potential as multi-target antidiabetic agents.

Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes

Discussion

Member takes

Implication

Key Points

Cite This Study

Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes

Discussion

Member takes

Implication

Key Points

Cite This Study

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