Key result
Alpha-thrombin-induced activation in human platelets involves two distinct high and moderate affinity pathways and a recently identified functional thrombin receptor.
This review summarizes early evidence on the dual pathways of alpha-thrombin-induced platelet activation and the role of a newly cloned thrombin receptor.
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Remains hypothesis-generating for thrombin receptor pathways; leaves open clinical translation to targeted antithrombotics.
The interpretive review represents evidence for two pathways of α-thrombin-induced activation in human platelets and evaluates the possible roles of a functional thrombin receptor recently identified by expression cloning. [P.S.E.B.M. 1991, Vol 198]
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Greco et al. (1991) studied this question. Alpha-thrombin-induced activation in human platelets involves two distinct high and moderate affinity pathways and a recently identified functional thrombin receptor.
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