The study hypothesizes that glycoprotein I (GP-I) on the platelet surface may serve as the receptor for thrombin, based on reduced binding observed in Bernard-Soulier syndrome.
Hypothesizes GP-I as thrombin receptor; leaves open validation in human platelets and clinical relevance.
The initial step in the interaction of thrombin with human platelets is binding of thrombin to specific structures on the platelet surface. Data are presented which show that platelets from thrombasthenic patients bind thrombin similar to controls. In contrast, platelets from a patient with Bernard-Soulier syndrome had lower thrombin binding capacity. It is suggested that glycoprotein one (GP-I) on the platelet surface might be the receptor for thrombin.
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P. Ganguly (1977) studied this question.
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