Key result
Thrombin exosite 1 is essential for binding to a hydrophilic domain on the N-terminal of platelet membrane glycoprotein Ib alpha, promoting thrombin receptor-coupled responses.
Population
Platelets and platelet membrane glycoprotein Ib (GPIb)
Design
Review
Authors
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May inform exosite 1-targeted antithrombotic design; leaves open clinical translation and net benefit.
This review details the molecular interaction between thrombin and platelet glycoprotein Ib, providing mechanistic insights into thrombin-induced platelet activation.
Jandrot‐Perrus et al. (1996) conducted a review in Platelet activation. Thrombin interaction with Glycoprotein Ib was evaluated. Thrombin exosite 1 is essential for binding to a hydrophilic domain on the N-terminal of platelet membrane glycoprotein Ib alpha, promoting thrombin receptor-coupled responses.
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