What does this research mean for the field?

Fibrinogen, fibronectin, von Willebrand factor, and thrombospondin share a related mechanism of binding to thrombin-stimulated platelets, likely involving shared or proximal binding sites on the glycoprotein IIb-IIIa complex. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1985BloodOpen Access

Related binding mechanisms for fibrinogen, fibronectin, von Willebrand factor, and thrombospondin on thrombin-stimulated human platelets

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Population

Thrombin-stimulated human platelets

Design

Preclinical

Authors

EPEF PlowScripps Research Institute RMRP McEverScripps Health BCBS CollerBrigham and Women's Hospital

Discussion

Member takes

Implication

Supports shared GPIIb-IIIa mechanism for multiple platelet ligands; hypothesis-generating for targeted adhesion modulation.

Structured PICO

Population

Thrombin-stimulated human platelets

Intervention

Monoclonal antibodies reacting with platelet membrane glycoproteins (GP) IIb and/or IIIa (Tab, PMI-1, 10E5, 2G12, T10)

Outcome

Binding of fibrinogen, fibronectin, von Willebrand factor, and thrombospondin to stimulated plateletssurrogate

Fibrinogen, fibronectin, von Willebrand factor, and thrombospondin share a related mechanism of binding to thrombin-stimulated platelets, likely involving the GPIIb-IIIa complex.

Cite This Study

Plow et al. (1985) studied this question.

synapsesocial.com/papers/6a12656ef7bd4f5c7da63d88 https://doi.org/10.1182/blood.v66.3.724.bloodjournal663724

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Bookmark

Related binding mechanisms for fibrinogen, fibronectin, von Willebrand factor, and thrombospondin on thrombin-stimulated human platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Related binding mechanisms for fibrinogen, fibronectin, von Willebrand factor, and thrombospondin on thrombin-stimulated human platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider