Key result
Long noncoding RNAs play key regulatory roles in pathological cardiac remodeling, acting primarily as endogenous sponges for specific miRNAs to regulate target gene expression.
Why the study?
Control of cardiac remodeling remains unsatisfactory, necessitating further exploration of underlying mechanisms and optimal therapeutic targets.
This review highlights the emerging role of long noncoding RNAs and their interactions with miRNAs in maladaptive cardiac remodeling, suggesting their potential as therapeutic targets.
Cardiac remodeling control remains unsatisfactory despite advances; leaves open mechanistic targets for future therapies.
Cardiac remodeling is a self-regulatory response of the myocardium and vasculature under the stressful condition. Cardiomyocytes (CMs), vascular smooth muscle cells (VSMCs), endothelial cells (ECs), and cardiac fibroblasts (CFs) are all involved in this process, characterized by change of morphological structures and mechanical/chemical activities as well as metabolic patterns. Despite current development of consciousness, the control of cardiac remodeling remains unsatisfactory, and to further explore the underlying mechanism and seek the optimal therapeutic targets is still the urgent need in clinical practice. It is now emerging that long noncoding RNAs (lncRNAs) play key regulatory roles in these adverse responses: lncRNA TUG1, AK098656, TRPV1, GAS5, Giver, and Lnc-Ang362 have been indicated in hypertension-related vascular remodeling, H19, TUG1, UCA1, MEG3, APPAT, and lincRNA-p21 in atherosclerosis (AS), and HIF1A-AS1 and Lnc-HLTF-5 in aortic aneurysm (AA). In addition, Neat1, AK139328, APF, CAIF, AK088388, CARL, MALAT1, HOTAIR, XIST, and NRF are involved in postischemia myocardial remodeling, while Mhrt, Chast, CHRF, ROR, H19, Plscr4, and MIAT are involved in myocardial hypertrophy, and MALAT1, wisper, MEG3, and H19 are involved in extracellular matrix (ECM) reconstitution. Signaling to specific miRNAs by acting as endogenous sponge (ceRNA) was the main form that regulates the target gene expression during cardiac remodeling. This review will underline the updates of lncRNAs and lncRNA-miRNA interactions in maladaptive remodeling and also cast light on their potential roles as therapeutic targets, hoping to provide supportive background for following research.
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Zhou et al. (2019) conducted a review in Pathological Cardiac Remodeling. Long noncoding RNAs (lncRNAs) was evaluated. Long noncoding RNAs play key regulatory roles in pathological cardiac remodeling, acting primarily as endogenous sponges for specific miRNAs to regulate target gene expression.
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