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A randomized, double-blind, placebo-controlled study was done on 106 volunteers to assess the effectiveness of chlorpheniramine maleate against the common cold. The results suggest that this antihistamine is significantly effective in relieving the symptoms of a cold if used four times daily for one week, and that relief was gained with no significant increase in side effects.
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CRUTCHER et al. (1981) studied this question.
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