Key result
Entacapone did not influence haemodynamics or plasma catecholamine levels during exercise, but altered catecholamine metabolism, increasing DHPG by up to 100% and decreasing MHPG by up to 29%.
Why the study?
Does entacapone alter haemodynamic responses and catecholamine metabolism during exercise in healthy male subjects?
Does entacapone alter haemodynamic responses and catecholamine metabolism during exercise in healthy male subjects?
Entacapone alters peripheral catecholamine metabolism without affecting haemodynamics or circulating catecholamine levels during exercise in healthy subjects.
Extends knowledge of COMT inhibition on catecholamine metabolites during exercise; leaves open relevance to clinical populations.
Catechol-O-methyltransferase (COMT) inhibition might be assumed to potentiate the effects of circulating catecholamines, particularly under conditions of enhanced catecholamine release. 2. The purpose of the present study was to establish whether the novel COMT inhibitor, entacapone, changes haemodynamic responses and catecholamine metabolism during exercise. 3. Entacapone was given orally to 12 healthy male subjects (age 23-30 years) in increasing single doses from 0 mg (control day) to 200 mg. A submaximal exercise test was performed on a bicycle ergometer, and blood pressure, heart rate and ECG were recorded. The concentrations of noradrenaline, adrenaline, DHPG (3,4-dihydroxyphenylglycol), MHPG (3-methoxy-4-hydroxyphenyl-glycol) and, DOPAC (3,4-dihydroxyphenylacetic acid) in plasma were determined. 4. Entacapone did not influence haemodynamics or ECG at rest or during exercise. 5. Entacapone did not influence plasma catecholamine levels, either at rest or during exercise. However, it altered the metabolic profile of catecholamines, which was shown by increases in the plasma concentrations of the monoamine oxidase-dependent metabolites DHPG (by up to 100%) and DOPAC (by up to 53%), and by a decrease of the COMT-dependent metabolite MHPG (by up to 29%).
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Sundberg et al. (1993) studied Healthy (n=12). Entacapone vs. 0 mg (control day) was evaluated on Haemodynamic responses and catecholamine metabolism during exercise. Entacapone did not influence haemodynamics or plasma catecholamine levels during exercise, but altered catecholamine metabolism, increasing DHPG by up to 100% and decreasing MHPG by up to 29%.
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