Why the study?
Does captopril alter sympathetic nervous system activity during basal conditions and physical exercise in patients with essential hypertension?
Population
9 patients (7 males, 2 females) with essential hypertension, aged 36-59 years.
Comparison
Captopril given orally in increasing dosages for… vs Baseline (before medication).
Design
Cohort
Follow-up
7 days
Authors
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Captopril lowers BP without affecting sympathetic activity at rest or exercise; supports mechanism dissociation but leaves open generalizability beyond this cohort.
Does captopril alter sympathetic nervous system activity during basal conditions and physical exercise in patients with essential hypertension?
Captopril effectively lowers blood pressure and angiotensin II in hypertensive patients without significantly altering sympathetic nervous system activity during rest or exercise.
Manhem et al. (1981) studied this question.
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