Why the study?
Does acute oral captopril affect hemodynamic responses at rest and during exercise in normal sodium-replete male volunteers?
Population
6 normal sodium-replete male volunteers
Comparison
25 mg of oral Captopril (acute administration) vs Placebo
Design
Other
Follow-up
Acute (at rest and during exercise)
Authors
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Reduces upright BP without impairing VO2peak in healthy volunteers; leaves open translation to patients with hypertension or HF.
Does acute oral captopril affect hemodynamic responses at rest and during exercise in normal sodium-replete male volunteers?
Acute ACE inhibition with captopril reduces blood pressure and systemic vascular resistance in the upright position at rest and during exercise without affecting peak oxygen uptake.
Fagard et al. (1982) studied this question.
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