Molecular analysis reveals instability in the SCCmec element affecting adjacent genes in methicillin-resistant Staphylococcus aureus, highlighting mechanisms altering diagnostic markers.
Staphylococcal cassette chromosome mec (SCC mec ) represents a sequence of clear clinical and diagnostic importance in staphylococci. At a minimum the chromosomal cassette contains the mecA gene encoding PBP2a but frequently also includes additional antibiotic resistance genes (e.g., ermA and aadC ; macrolide and aminoglycoside resistance, respectively).
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Scharn et al. (2022) studied this question.
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