What question did this study set out to answer?

To evaluate whether patch testing with cobalt chloride 1.0% is more suitable than 0.5% and to investigate the concomitant rate of allergic reactivity to cobalt, nickel, and chromium.

September 30, 2020Contact Dermatitis

Suitable test concentration of cobalt and concomitant reactivity to nickel and chromium: A multicentre study from the Swedish Contact Dermatitis Research Group

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Authors

MIMarléne IsakssonMalmö University LHLina HagvallLund University BGBo GlasUmeå University

Discussion

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Implication

Multicenter study demonstrates that 1.0% cobalt chloride detects significantly more contact allergies than 0.5% in patch-tested patients, indicating the need to update standard diagnostic series.

Key Points

To evaluate whether patch testing with cobalt chloride 1.0% is more suitable than 0.5% and to investigate the concomitant rate of allergic reactivity to cobalt, nickel, and chromium.
Conducted a multicenter patch test investigation in Sweden comparing diagnostic sensitivity between cobalt chloride 1.0% and 0.5% in petrolatum.
Assessed simultaneous co-reactivity among patients positive for cobalt, chromium, and nickel allergies.
Contact allergy to cobalt was identified in 6.6% (90 patients), with cobalt chloride 0.5% failing to detect 41.1% (37/90) of cases compared to 0.7% (10 patients) missed by cobalt 1.0% (P < .001).
Solitary cobalt allergy without concomitant nickel reactivity occurred in 61.1% of cobalt-positive individuals, while chromium and nickel allergies occurred in 2.6% and 13.3% of the total cohort, respectively.
Female patients exhibited significantly higher rates of positive reactions than males to both cobalt (P = .036) and nickel (P < .001), with zero instances of patch test sensitization observed.

Cite This Study

Isaksson et al. (2020) studied this question.

synapsesocial.com/papers/6aa040f3742952fb2b176d01 https://doi.org/10.1111/cod.13710

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Implication

Multicenter study demonstrates that 1.0% cobalt chloride detects significantly more contact allergies than 0.5% in patch-tested patients, indicating the need to update standard diagnostic series.

Suitable test concentration of cobalt and concomitant reactivity to nickel and chromium: A multicentre study from the Swedish Contact Dermatitis Research Group

Discussion

Member takes

Implication

Key Points

Cite This Study

Suitable test concentration of cobalt and concomitant reactivity to nickel and chromium: A multicentre study from the Swedish Contact Dermatitis Research Group

Discussion

Member takes

Implication

Key Points

Cite This Study

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