Key result
A fetal autopsy case report detailed the histopathological findings of hypoplastic left heart syndrome with parchment left ventricle following medical termination at 20 weeks of gestation.
Case Report (n=1)
This case report details the rare perinatal autopsy findings of a fetus with hypoplastic left heart syndrome and parchment left ventricle.
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Supports fetal echocardiography for HLHS diagnosis; extends rare autopsy correlations but leaves broader validation open.
Hypoplastic left heart syndrome (HLHS) refers to the abnormal development of the left-sided cardiac structures, resulting in obstruction to blood fl ow from the left ventricular outfl ow tract. In addition, the syndrome includes underdevelopment of the left ventricle, aorta, and aortic arch, as well as mitral atresia or stenosis. The syndrome can be diagnosed by fetal echocardiography between 18 and 22 weeks of gestation. This is a fetal autopsy case report of HLHS, which was diagnosed on ultrasonography and medically terminated at 20 weeks of gestation. The autopsy and histopathological fi ndings are discussed in detail. Some important aspects of epidemiology, prenatal diagnosis, and current literature on HLHS are highlighted.
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Chatura et al. (2015) conducted a case report in Hypoplastic left heart syndrome (HLHS) (n=1). A fetal autopsy case report detailed the histopathological findings of hypoplastic left heart syndrome with parchment left ventricle following medical termination at 20 weeks of gestation.
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