Key result
In five pigs with icterus and wasting from two farms, PCV2b genotype was detected in several organs, and three pigs showed lymphohistiocytic, periportal hepatitis.
Case Report (n=5)
Yes
Icterus and periportal hepatitis can be rare clinical signs of porcine circovirus type 2 systemic disease in pigs.
Icterus in wasted pigs may indicate PCV2; leaves open whether targeted diagnostics improve herd outcomes.
SUMMARY Icterus is a yellow discolouration of tissue and blood plasma due to a disorder of the bilirubin metabolism. This case report describes two porcine circovirus type 2 (PCV2) outbreaks in a fattening farm (F1) and a breeding farm (F2). At F1, pigs had intradermal bleedings and wasting, and three pigs showed icterus. At F2, suckling and weaning pigs (WPs) had an icterus and were wasted. Three fattening pigs (F1), one suckling piglet and one WP (F2) were dissected. Additional investigations included histology, PCV2 immunohistochemistry (IHC), fluorescence in situ hybridisation (FISH) of tissue samples, PCR including sequencing of the PCV2 strains and next‐generation sequencing (NGS) of liver samples. Three of the five dissected pigs showed a lymphohistiocytic, periportal hepatitis with disruption of the hepatic cord architecture. PCV2 was detected by IHC, FISH, PCR and NGS in several organs of the pigs. In both farms, sequencing revealed a PCV2b genotype.
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Graage et al. (2020) conducted a case report in Porcine circovirus type 2 systemic disease with icterus (n=5). Porcine circovirus type 2 (PCV2) infection was evaluated on Histological and virological findings in dissected pigs. In five pigs with icterus and wasting from two farms, PCV2b genotype was detected in several organs, and three pigs showed lymphohistiocytic, periportal hepatitis.
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