Key result
Quantitative trait locus analysis has identified numerous loci regulating HDL, LDL, and triglycerides, with 80% to 100% concordance between mouse and human homologous regions.
There is high concordance between mouse and human quantitative trait loci for plasma lipids, supporting the use of mouse models to identify novel therapeutic targets for atherosclerosis.
Supports mouse models for lipid QTL discovery; extends concordance data but leaves open therapeutic translation pending functional validation.
PURPOSE OF REVIEW: Quantitative trait locus analysis has been used in both humans and mice for the purpose of finding new genes regulating plasma lipid levels. We review these methods and discuss new approaches that can help find quantitative trait locus genes. RECENT FINDINGS: Many quantitative trait loci have been found that regulate plasma levels for HDL cholesterol (37 in mice and 30 in humans), LDL cholesterol (25 in mice and 20 in humans) and triglycerides (19 in mice and 30 in humans). Most of the human quantitative trait loci have concordant mouse quantitative trait loci mapping to homologous regions (93% for HDL cholesterol, 100% for LDL cholesterol and 80% for triglycerides), suggesting that many genes identified in mice may also regulate the same traits in humans. New approaches based on recently developed genomic and bioinformatic technologies and resources should greatly facilitate finding these genes. SUMMARY: New genes regulating plasma lipid levels can be found in mice and then tested in humans. Some of these genes could be potential therapeutic targets for human atherosclerosis.
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Wang et al. (2005) conducted a review in Plasma lipid concentrations. Quantitative trait locus analysis was evaluated on Identification of quantitative trait loci regulating plasma lipid levels. Quantitative trait locus analysis has identified numerous loci regulating HDL, LDL, and triglycerides, with 80% to 100% concordance between mouse and human homologous regions.
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