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January 1, 1981Carcinogenesis

The relationship between the carcinogenicity and mutagenicity of nitrosamines in a hepatocyte-mediated mutagenicity assay

Carol Jones Phyllis J. Marlino William Lijinsky Eliezer Huberman

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Abstract

A quantitative relationship was established for 26 nitrosamines between their carcinogenic effectiveness in experimental animals and their mutagenic activity in a mammalian cell-mediated assay. Mutagenesis was measured in Chinese hamster V79 cells co-cultivated with primary rat hepatocytes, which are capable of activating nitrosamines. Resistance to ouabain and to 6-thioguanine served as the genetic markers.

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Jones et al. (1981) studied this question.

synapsesocial.com/papers/6aa04324e47507b787628613 https://doi.org/10.1093/carcin/2.10.1075

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