Key result
Administration of dicoumarol to patients receiving chlorpropamide increased the half-life of chlorpropamide from about 40 hours to about 90 hours, leading to drug accumulation.
Why the study?
Does dicoumarol administration cause accumulation of chlorpropamide in patients receiving chlorpropamide?
Case Report
Does dicoumarol administration cause accumulation of chlorpropamide in patients receiving chlorpropamide?
Dicoumarol interacts with chlorpropamide, significantly increasing its half-life and risking hypoglycaemic attacks.
Answers are grounded in this paper and cite their sources.
Potential hypoglycemia risk with dicoumarol-chlorpropamide coadministration merits vigilance; case report leaves interaction open for confirmation.
A description is given of a patient who had received 375 mg chlorpropamide daily for two years for Parkinsonism. Three months after the institution of anticoagulant therapy with dicoumarol he had a hypoglycaemic attack. The chlorpropamide concentration in the serum was remarkably high. Clinical experiments revealed that the administration of dicoumarol to patients who are receiving chlorpropamide leads to accumulation of the latter. The half‐life of chlorpropamide in the blood is increased from the normal value of about 40 hours to about 90 hours during treatment with dicoumarol.
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Kristensen et al. (1968) conducted a case report in Patients receiving chlorpropamide. Dicoumarol vs. Chlorpropamide without dicoumarol was evaluated on Half-life of chlorpropamide in the blood. Administration of dicoumarol to patients receiving chlorpropamide increased the half-life of chlorpropamide from about 40 hours to about 90 hours, leading to drug accumulation.
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