Testis determining gene(s) on the X chromosome short arm: chromosomal localisation and possible role in testis determination.

Testis determining gene(s) on the X chromosome short arm: chromosomal localisation and possible role in testis determinationRecently, we have proposed that a testis determining gene(s) subject to X inactivation is present on Xp (TDF-X), and that two active copies of TDF-X hinder testis formation in the presence of SRY.' In this follow up letter, we refine the chromosomal location of TDF-X, and speculate on the role of TDF-X in testis determination.For chromosomal localisation, we surveyed 22 3 22.1 21.3 21 2 21.1 11.4