Outcome of Differentiated Thyroid Cancer with Detectable Serum Tg and Negative Diagnostic 131I Whole Body Scan: Comparison of Patients Treated with High 131I Activities Versus Untreated Patients

This is the authors' abstract. We don't add key points for this paper.

Detectable serum Tg levels associated with negative diagnostic 131I whole body scan are not infrequently found in patients with differentiated thyroid cancer. Several researchers have shown that in these patients the administration of high 131I activity (100 mCi or more) increases the sensitivity of a posttherapy diagnostic 131I whole body scan performed a few days later and allows the detection of neoplastic foci not seen with diagnostic doses of 131I. Empirical radioiodine treatment has also been advocated by some researchers, but its therapeutic effect is controversial.