Key result
Shorter adult height in premenopausal women without CVD was associated with a higher likelihood of hypercholesterolemia (ptrend=0.002), hypertriglyceridemia (ptrend=0.010), and low HDL-C (ptrend=0.002).
Why the study?
The mechanism underlying the association between height and cardiovascular disease remains unclear, prompting exploration of the relationship between height and dyslipidemia in premenopausal women.
Is shorter adult height associated with an increased prevalence of dyslipidemia in premenopausal women without cardiovascular disease?
Cross-Sectional (n=16,361)
Is shorter adult height associated with an increased prevalence of dyslipidemia in premenopausal women without cardiovascular disease?
Shorter adult height is independently associated with an adverse lipid profile in premenopausal Korean women, suggesting dyslipidemia may mediate the known link between short stature and cardiovascular disease.
BACKGROUND: The association between height and cardiovascular disease (CVD) has been reported in epidemiological studies for decades; however, the mechanism for this relationship is still unclear. We previously reported that dyslipidemia was associated with adult height in Korean men without CVD. OBJECTIVES: This study explored the potential -relationship between height and dyslipidemia in premenopausal women. METHODS: This study used data from the 2007-2016 Korea National Health and Nutritional Examination Survey (KNHANES). We identified 16,361 premenopausal women aged ≥19 years without a history of CVD (myocardial infarction/stroke) or cancer. Fasting total cholesterol, triglyceride, and high-density lipoprotein cholesterol (HDL-C) levels were measured. Dyslipidemia was further classified as hypercholesterolemia (total cholesterol level ≥240 mg/dL or treatment with lipid-lowering medications), hypertriglyceridemia (triglyceride level ≥200 mg/dL), and low HDL-C (HDL-C level <40 mg/dL). Subjects were divided into four groups by their height (<155, 155-159.9, 160-164.9, and ≥165 cm), and the prevalence of dyslipidemia was compared. RESULTS: Multiple regression analysis revealed that short premenopausal women had a higher likelihood of hypercholesterolemia (ptrend = 0.002), hypertriglyceridemia (ptrend = 0.010), and low HDL-C (ptrend = 0.002) when adjusted for age, comorbidities, waist circumference, health-related habits, and economic status. CONCLUSION: There was a dose-dependent correlation between adult height and adverse lipid profile in premenopausal Korean women who did not have CVD. This finding could serve as further evidence that dyslipidemia can be a link between shortness and CVD.
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Hwang et al. (2020) conducted a cross-sectional in Dyslipidemia (n=16,361). Height vs. Taller height categories was evaluated on Prevalence of dyslipidemia (hypercholesterolemia, hypertriglyceridemia, and low HDL-C) (p=ptrend = 0.002). Shorter adult height in premenopausal women without CVD was associated with a higher likelihood of hypercholesterolemia (ptrend=0.002), hypertriglyceridemia (ptrend=0.010), and low HDL-C (ptrend=0.002).
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