Key result
A 6.5-cm increase in genetically determined adult height reduced the odds of coronary heart disease by 10% (OR 0.90; 95% CI 0.85-0.95), with no significant association observed for stroke.
Why the study?
Does genetically determined taller adult height reduce the risk of coronary heart disease and stroke?
Population
60,028 participants across 21 studies, supplemented by summary data from the GIANT consortium and…
Comparison
Genetically determined adult height. vs Lower genetically determined adult height.
Design
Meta-analysis, Mendelian randomization
Authors
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Taller genetically determined height causally lowers coronary risk without stroke benefit; extends Mendelian randomization evidence on anthropometric traits.
Meta-Analysis (n=60,028)
Yes
Does genetically determined taller adult height reduce the risk of coronary heart disease and stroke?
Odds Ratio: 0.9 (95% CI 0.85–0.95)
Genetically determined taller adult height is causally associated with a lower risk of coronary heart disease, potentially mediated by better lung function and lower BMI, cholesterol, and blood pressure.
Nüesch et al. (2015) conducted a meta-analysis in Coronary heart disease and stroke (n=60,028). Adult height (6.5-cm increase) vs. Lower adult height was evaluated on Coronary heart disease (CHD) (OR 0.90, 95% CI 0.85-0.95). A 6.5-cm increase in genetically determined adult height reduced the odds of coronary heart disease by 10% (OR 0.90; 95% CI 0.85-0.95), with no significant association observed for stroke.
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