Key result
Complement component C9 immunohistochemistry detected myocardial deposits in 95% (19 of 20) of owl monkeys that died suddenly or were euthanized, suggesting acute myocardial infarction.
Why the study?
Owl monkeys occasionally die suddenly without clinical heart disease, but early myocardial infarction changes are difficult to detect using conventional stains and light microscopy.
Can complement component C9 immunohistochemistry detect early myocardial cell death in owl monkeys?
Observational (n=20)
Can complement component C9 immunohistochemistry detect early myocardial cell death in owl monkeys?
Complement component C9 immunohistochemistry is a useful diagnostic tool for detecting acute myocardial infarcts in owl monkeys.
Answers are grounded in this paper and cite their sources.
C9 IHC may detect occult myocardial injury in research primates; leaves open its diagnostic value pending prospective validation.
BACKGROUND: Owl monkeys are commonly used in biomedical research which is affected by the high incidence of cardiomyopathy in this species. Occasionally, owl monkeys with no clinical signs of heart disease are found dead and at necropsy show no, or very mild, cardiomyopathy. A possible explanation for sudden death is acute myocardial infarction; however, early myocardial changes may be difficult to assess by conventional stains and light microscopy. METHODS: Complement component C9 immunohistochemistry was performed in paraffin-embedded heart tissue samples from owl monkeys who died suddenly, or were euthanized due to sickness, to determine whether these animals suffered from acute myocardial infarcts. RESULTS AND CONCLUSION: C9 deposits were found in the myocardium of 19 out of 20 (95%) animals. The findings in this study suggest owl monkeys suffer from acute myocardial infarcts, and complement component C9 immunohistochemistry may be a useful diagnostic tool.
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Gozalo et al. (2021) conducted an observational in Suspected acute myocardial infarction / sudden death (n=20). Complement component C9 immunohistochemistry was evaluated on C9 deposits in the myocardium. Complement component C9 immunohistochemistry detected myocardial deposits in 95% (19 of 20) of owl monkeys that died suddenly or were euthanized, suggesting acute myocardial infarction.
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