Key result
C4d and C9 immunohistochemistry reacted strongly with necrotic myocytes in 100% of early myocardial infarctions (up to 2 days), demonstrating utility in delineating acute myocardial infarction.
Why the study?
Does immunohistochemistry for C4d, C9, and troponin T accurately delineate acute myocardial infarction in autopsy tissue?
Population
26 autopsy cases with a total of 54 myocardium areas of infarction, and 5 control cases without evidence of…
Comparison
Immunohistochemistry for C4d, C9, and troponin T… vs Histologically normal myocardium and 5 cases…
Design
Case-control
Authors
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Supports adjunctive C4d/C9 IHC for autopsy MI delineation; leaves open prospective validation before wider adoption.
Observational (n=31)
Does immunohistochemistry for C4d, C9, and troponin T accurately delineate acute myocardial infarction in autopsy tissue?
C4d and C9 immunohistochemistry are highly specific and sensitive markers for early myocardial infarction in autopsy tissue, outperforming troponin T.
Jenkins et al. (2010) conducted an observational in acute myocardial infarction (n=31). C4d, C9, and troponin T immunohistochemistry vs. Controls without infarction and internal histologically normal myocardium was evaluated on Reactivity and specificity of C4d, C9, and troponin T in necrotic myocytes. C4d and C9 immunohistochemistry reacted strongly with necrotic myocytes in 100% of early myocardial infarctions (up to 2 days), demonstrating utility in delineating acute myocardial infarction.
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