Key result
A single bout of resistance exercise significantly increased serum Klotho concentrations at 10 minutes post-exercise, though this increase did not correlate with the acute reduction in endothelial function.
Why the study?
Because Klotho protects vascular endothelial function and acute resistance-exercise-induced hypertensive stimulus causes endothelial dysfunction, the study investigated the impact of acute resistance exercise on serum Klotho and its relationship with flow-mediated dilation responses.
Does a single bout of resistance exercise affect serum Klotho and endothelial function in healthy young men?
Does a single bout of resistance exercise affect serum Klotho and endothelial function in healthy young men?
A single bout of resistance exercise acutely increases serum Klotho levels in healthy young men, though this increase does not prevent the transient reduction in endothelial function.
Acute resistance exercise raises Klotho without linking to FMD decline; leaves open its role in post-exercise endothelial responses.
BACKGROUND: It has been shown that Klotho protects vascular endothelial function. Given that a single bout of resistance-exercise-induced hypertensive stimulus causes endothelial dysfunction, we postulated that acute resistance exercise would reduce serum Klotho levels. In this respect, the reduction in serum Klotho levels would be associated with the response of flow-mediated dilation (FMD). Therefore, the purpose of this study was to investigate the impact of acute resistance exercise on the Klotho response in serum. In addition, we examined the relationship between the serum Klotho and FMD responses following acute resistance exercise. METHODS: Twelve untrained men participated in this study (20.4 ± 0.3 years). Following baseline measurements (blood pressure, blood collection, FMD), subjects performed leg extensions, which consisted of 10 repetitions for five sets at 70% of one-repetition maximum. After the exercise, measurement of blood pressure, blood collection, and FMD assessment were repeated for 60 min. We analyzed Klotho and endothelin-1 (ET-1) concentrations in blood serum. RESULTS: As expected, the exercise significantly elevated blood pressure and led to decreased FMD (p < 0.05). However, Klotho concentrations were significantly increased following exercise (p < 0.05). No correlation was observed in Klotho and FMD responses following acute resistance exercise. However, there was a significant positive correlation between Klotho and ET-1 in response to resistance exercise (p < 0.05). CONCLUSION: In conclusion, the present study reveals that serum Klotho significantly increased following a single bout of resistance exercise. However, the increase in Klotho may not associate with the acute reduction in endothelial function.
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Morishima et al. (2021) studied Healthy (n=12). Single bout of resistance exercise vs. Baseline (pre-exercise) was evaluated on Serum Klotho concentration (p=<0.05). A single bout of resistance exercise significantly increased serum Klotho concentrations at 10 minutes post-exercise, though this increase did not correlate with the acute reduction in endothelial function.
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