Key result
Acute resistance exercise reduces flow-mediated dilation ~30% in trained young adults.
Why the study?
The effects of a single resistance exercise session on endothelial function measured by flow-mediated dilation are divergent and inconclusive.
Does a single resistance exercise session reduce flow-mediated dilation in healthy young resistance-trained individuals?
RCT (n=11)
Randomized in a balanced way (1:1)
No
Does a single resistance exercise session reduce flow-mediated dilation in healthy young resistance-trained individuals?
Standardized Mean Difference: 1.05
Absolute Event Rate: 4.03% vs 5.73%
p-value: p=<0.01
A single session of resistance exercise acutely reduces flow-mediated dilation, a surrogate marker of endothelial function, in healthy young trained individuals.
May indicate transient endothelial impairment post-exercise; hypothesis-generating for vascular effects of resistance training in healthy adults.
The current pool of data investigating the effects of a single resistance exercise session on endothelial function is divergent and inconclusive. Therefore, the purpose of the present study was to evaluate the effect of a single resistance exercise session on flow-mediated dilation (FMD) in trained individuals. Eleven healthy, young, recreationally resistance-trained individuals participated in the study. After determining the resistance exercise workload, the participants performed three sets of 10–12 repetition of leg press and leg extension exercises. By using ultrasound equipment, brachial artery FMD was assessed before (PRE) and 30 min after (POST) the resistance exercise protocol or resting (control) to evaluate endothelial function. A significant reduction in FMD response (PRE: 5.73% ± 1.21% vs. POST: 4.03% ± 1.94%, p < 0.01) after resistance exercise was observed, accompanied by a large effect size (d = 1.05). No significant difference was observed in FMD in the control condition (PRE: 5.82% ± 1.19% vs. POST: 5.66% ± 1.24%, p = 0.704). Additionally, no significant difference in baseline brachial artery diameter between resistance exercise (PRE: 3.30 ± 0.32 vs. POST: 3.40 ± 0.34 mm, p = 0.494) and resting (PRE: 3.64 ± 0.41 vs. POST: 3.67 ± 0.62 mm, p = 0.825) was observed. Our findings showed that a single resistance exercise session induced a reduction in FMD in resistance-trained individuals.
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Oliveira et al. (2020) conducted an RCT in Healthy, recreationally resistance-trained (n=11). Single resistance exercise session vs. Baseline (pre-exercise) was evaluated on Flow-mediated dilation (FMD) response (d = 1.05, p=<0.01). A single resistance exercise session significantly reduced flow-mediated dilation from 5.73% at baseline to 4.03% (p<0.01) in healthy, resistance-trained young individuals.
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