Key result
Repeated bouts of endurance exercise increased extracellular glycerol concentration 1.2-fold compared to the initial bout, suggesting atrial natriuretic peptide contributes to stimulated lipolysis.
Why the study?
Does atrial natriuretic peptide contribute to lipid mobilization during repeated bouts of endurance exercise in healthy males?
Does atrial natriuretic peptide contribute to lipid mobilization during repeated bouts of endurance exercise in healthy males?
Atrial natriuretic peptide contributes to the stimulation of lipolysis in subcutaneous adipose tissue during repeated bouts of endurance exercise.
May support ANP role in repeated-exercise lipolysis in healthy males; leaves open clinical relevance and need for confirmatory trials.
Atrial natriuretic peptide (ANP) controls lipolysis in human adipocytes. Lipid mobilization is increased during repeated bouts of exercise, but the underlying mechanisms involved in this process have not yet been delineated. The relative involvement of catecholamine- and ANP-dependent pathways in the control of lipid mobilization during repeated bouts of exercise was thus investigated in subcutaneous adipose tissue (SCAT) by microdialysis. The study was performed in healthy males. Subjects performed two 45-min exercise bouts (E1 and E2) at 50% of their maximal oxygen uptake separated by a 60-min rest period. Extracellular glycerol concentration (EGC), reflecting SCAT lipolysis, was measured in a control probe perfused with Ringer solution and in two other probes perfused with either Ringer plus phentolamine (alpha(1/2)-AR antagonist) or Ringer plus both phentolamine and propranolol (beta-AR antagonist). Plasma epinephrine, plasma glycerol, and EGC were 1.7-, 1.6-, and 1.2-fold higher in E2 than in E1, respectively. Phentolamine potentiated exercise-induced EGC increase during E2 only. Propranolol reduced the lipolytic rate during both E1 and E2 compared with the probe with phentolamine. Plasma ANP concentration increased more during E2 than during E1 and was correlated with the increase in EGC in the probe containing phentolamine plus propranolol. The results suggest that ANP is involved in the control of lipolysis during exercise and that it contributes to stimulation of lipolysis during repeated bouts of exercise.
No takes yet. Share an insight, caveat, or question.
Moro et al. (2005) studied Healthy. Repeated bouts of endurance exercise vs. First exercise bout (E1) was evaluated on Extracellular glycerol concentration (EGC) reflecting subcutaneous adipose tissue lipolysis (1.2-fold higher in E2 than in E1). Repeated bouts of endurance exercise increased extracellular glycerol concentration 1.2-fold compared to the initial bout, suggesting atrial natriuretic peptide contributes to stimulated lipolysis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: