Key result
Increasing doses of EPA and DHA up to 1.8 g/d for 1 year did not significantly influence endothelial function measured by flow-mediated dilatation compared to placebo (P=0.781).
RCT (n=367)
Double-blind
Randomized
p-value: p=0.781
No benefit on endothelial function with up to 1.8 g/d EPA+DHA; confirms lack of effect on FMD and questions vascular benefit in this dose range.
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Sanders et al. (2011) conducted an RCT in Healthy adults at moderate risk of CVD (n=367). EPA and DHA (long chain n-3 PUFA) vs. Placebo (olive oil BP) was evaluated on Endothelial function measured by flow-mediated dilatation (FMD) of the brachial artery (p=0.781). Increasing doses of EPA and DHA up to 1.8 g/d for 1 year did not significantly influence endothelial function measured by flow-mediated dilatation compared to placebo (P=0.781).
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