Key result
Transbronchial lung biopsy successfully diagnosed pulmonary tumor thrombotic microangiopathy in a 60-year-old man with esophageal squamous cell carcinoma, the first reported case of this association.
Case Report (n=1)
No
This is the first reported case of pulmonary tumor thrombotic microangiopathy (PTTM) associated with esophageal squamous cell carcinoma, successfully diagnosed antemortem via transbronchial lung biopsy.
Antemortem transbronchial biopsy can diagnose PTTM in esophageal cancer; first case leaves open broader validation and causality.
Pulmonary tumor thrombotic microangiopathy (PTTM) is an uncommon cancer-related complication that has been most frequently reported to be associated with adenocarcinoma. We present a case of PTTM which developed in a 60-year-old man with esophageal carcinoma. One year after definitive treatment of the tumor, he developed pulmonary hypertension. Transbronchial lung biopsy (TBLB) specimens showed fibrocellular intimal proliferation and luminal stenosis of the small pulmonary vessels, which contained squamous cell carcinoma cells. Thus, PTTM associated with esophageal carcinoma was diagnosed. This is the first reported case of PTTM associated with esophageal squamous cell carcinoma. TBLB seemed to be useful for obtaining a definitive diagnosis.
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Ueda et al. (2011) conducted a case report in Pulmonary tumor thrombotic microangiopathy (PTTM) associated with esophageal squamous cell carcinoma (n=1). Transbronchial lung biopsy (TBLB) and chemotherapy was evaluated on Diagnosis and clinical course of PTTM. Transbronchial lung biopsy successfully diagnosed pulmonary tumor thrombotic microangiopathy in a 60-year-old man with esophageal squamous cell carcinoma, the first reported case of this association.
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