Key result
Patients with hyperventilation syndrome had significantly higher ventilatory equivalents for oxygen during light exercise compared to controls (35.2 vs 23.1; p<0.01).
Why the study?
Does exercise testing reveal elevated ventilatory equivalents in patients with hyperventilation syndrome compared to controls?
Case-Control (n=20)
Does exercise testing reveal elevated ventilatory equivalents in patients with hyperventilation syndrome compared to controls?
Absolute Event Rate: 35.2% vs 23.1%
p-value: p=<0.01
Exercise testing demonstrates elevated ventilatory equivalents in hyperventilation syndrome, suggesting it can aid diagnosis without invasive arterial cannulation.
Elevated ventilatory equivalents during light exercise were associated with hyperventilation syndrome; leaves open its diagnostic utility pending prospective validation.
In hyperventilation syndrome (HVS), hyperventilation is often provoked by exercise. This study was undertaken to investigate gas exchange parameters and their correlation to arterial blood gas values in HVS patients during exercise. Ventilatory equivalents for oxygen (VE/VO2) and carbon dioxide (VE/VCO2) were significantly higher in HVS patients than in the controls. (VE/VO2) during light exercise (40-50 W) was 23.1 +/- 2.7 (n = 10) in the controls and 35.2 +/- 8.2 (n = 10) in the HVS group (p < 0.01). VE/VCO2 during light exercise was 30.0 +/- 3.3 in the controls and 41.8 +/- 6.0 in the HVS group (p < 0.01). In HVS, significantly correlations were observed between VE/VCO2 and PaCO2, and between VE/VO2 and PaCO2 during both light and maximal exercise (p < 0.02). The findings suggest that exercise testing can be used to aid HVS diagnosis without invasive arterial cannulation.
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Kinnula et al. (2009) conducted a case-control in Hyperventilation Syndrome (n=20). Hyperventilation syndrome vs. Controls was evaluated on Ventilatory equivalents for oxygen (VE/VO2) during light exercise (p=<0.01). Patients with hyperventilation syndrome had significantly higher ventilatory equivalents for oxygen during light exercise compared to controls (35.2 vs 23.1; p<0.01).
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