Key result
Exercise VE/VCO2 positively correlates with hypercapnic ventilatory response in chronic heart failure.
Why the study?
In heart failure, an increased ventilatory response to exercise is typically attributed to ventilation-perfusion mismatch, but the role of respiratory centre responsiveness to carbon dioxide remained unclear.
Is the ventilatory response to exercise correlated with the hypercapnic ventilatory response in patients with chronic heart failure?
Population
31 patients with chronic heart failure and LVEF < 40% and 25 controls
Comparison
Patients with chronic heart failure vs controls
Design
Cross-sectional comparative study
Authors
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Supports CO2 chemosensitivity contribution to exercise hyperventilation in HF; extends healthy-subject observations but remains hypothesis-generating.
Cross-Sectional (n=56)
Is the ventilatory response to exercise correlated with the hypercapnic ventilatory response in patients with chronic heart failure?
Effect estimate: r = 0.70
p-value: p=< 0.00001
In patients with heart failure, the increased ventilatory response to exercise is positively correlated with the hypercapnic ventilatory response, suggesting it is partly mediated by the responsiveness of the respiratory center.
Andreas et al. (1996) conducted a cross-sectional in Chronic heart failure (n=56). Chronic heart failure vs. Controls was evaluated on Correlation between VE/VCO2 during exercise and hypercapnic ventilatory response (r = 0.70, p=< 0.00001). In patients with chronic heart failure, the ventilatory response to exercise (VE/VCO2) was positively correlated with the hypercapnic ventilatory response (r = 0.70; P < 0.00001).
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