Key result
Systemic sclerosis was associated with a significantly higher prevalence of carotid plaque compared with matched controls (45.6% vs 19.5%, P=0.01).
Why the study?
Is the prevalence of subclinical atherosclerosis increased in female patients with systemic sclerosis compared to matched controls, and is it associated with specific serum proteins?
Cross-Sectional (n=92)
Is the prevalence of subclinical atherosclerosis increased in female patients with systemic sclerosis compared to matched controls, and is it associated with specific serum proteins?
Absolute Event Rate: 45.6% vs 19.5%
p-value: p=0.01
Female patients with systemic sclerosis have a higher prevalence of carotid plaque than matched controls, which correlates with elevated serum proteins implicated in vasculopathy and fibrosis.
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SSc patients show higher carotid plaque prevalence; leaves open whether serum protein biomarkers improve risk stratification in this population.
Schiopu et al. (2013) conducted a cross-sectional in Systemic sclerosis (n=92). Systemic sclerosis vs. Matched controls was evaluated on Presence of carotid plaque (p=0.01). Systemic sclerosis was associated with a significantly higher prevalence of carotid plaque compared with matched controls (45.6% vs 19.5%, P=0.01).
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