What question did this study set out to answer?

To review the potential of molecular biomarkers and emerging high-throughput technologies to enhance early detection and risk assessment strategies for colorectal cancer.

January 1, 2004Disease MarkersOpen Access

The Promise of Biomarkers in Colorectal Cancer Detection

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Authors

AUAsad UmarNational Cancer Institute SSSudhir SrivastavaIndian Agricultural Statistics Research Institute

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Implication

Narrative review highlights molecular biomarkers for early detection in colorectal cancer screening, suggesting high-throughput profiling improves curable-stage diagnosis.

Key Points

To review the potential of molecular biomarkers and emerging high-throughput technologies to enhance early detection and risk assessment strategies for colorectal cancer.
Synthesized evidence on epidemiological screening approaches, cost-effectiveness analyses, and barriers in early cancer detection research.
Evaluated advancements in high-throughput analytical platforms, including gene-expression microarrays, tissue arrays, protein arrays, and proteomics.
Current standard screening technologies struggle to reliably detect early localized lesions, limiting timely curative intervention.
High-throughput platforms such as gene-expression and protein microarrays offer improved sensitivity for identifying asymptomatic early-stage colorectal cancers.
Effective clinical translation requires coordinated integration across biomarker discovery laboratories, validation centers, clinical repositories, and population-wide screening programs.

Cite This Study

Umar et al. (2004) studied this question.

synapsesocial.com/papers/6aa04c9319271829a4cd72d8 https://doi.org/10.1155/2004/303016

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Implication

Narrative review highlights molecular biomarkers for early detection in colorectal cancer screening, suggesting high-throughput profiling improves curable-stage diagnosis.

The Promise of Biomarkers in Colorectal Cancer Detection

Discussion

Member takes

Implication

Key Points

Cite This Study

The Promise of Biomarkers in Colorectal Cancer Detection

Discussion

Member takes

Implication

Key Points

Cite This Study

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