Key result
Lycium barbarum fruit extract and methylxanthines from Pu-erh and Bancha tea leaves did not affect intracellular viral replication but significantly inhibited extracellular HSV-1 virions and viral adsorption.
Why the study?
Plant products are widely used in traditional medicine to improve human health, but the antiviral effects of Lycium barbarum fruit extract and methylxanthines from Pu-erh and Bancha tea leaves required evaluation.
Lycium barbarum fruit extract and methylxanthines from Pu-erh and Bancha tea leaves demonstrate in vitro inhibitory effects on extracellular virions and adsorption of HSV-1.
Answers are grounded in this paper and cite their sources.
May inhibit HSV-1 extracellularly in vitro; hypothesis-generating and should not change practice.
Introduction: Based on traditional medicine, many countries use various plant products (fruits, leaves and other plant parts) as food supplements or in the form of tea. The use of these plant sources has been established through the years of use and the proven benefits of their ingredients to improve human health. Aim: In the present study, we have focused on the effect of Lycium barbarum fruit extract and methylxanthines isolated from Pu-erh (MXP) and Bancha (MXB) tea leaves on Herpes simplex virus type 1 (HSV-1), poliovirus 1 (PV1) and coxsackievirus B1 (CVB1) virus in vitro. Materials and methods: We used in vitro antiviral and virus attachment assays to determine the effects of the three extracts we studied. Results: None of the extracts showed significant inhibition of replication of the three treated viruses but a remarkable inhibitory effect on extracellular virions of HSV-1 was exhibited 30 minutes after exposure, especially by the Lycium barbarum extract. The inhibitory effect of the three extracts on the level of adsorption of the HSV-1 to sensitive cells (MDBK) was also significant, with the most pronounced effect of the MXP. The protective effect of the extracts against herpes infection on healthy cells was also determined, the MXP showing the most notable effect. Conclusions: The three studied extracts can be used effectively in the treatment of herpes infections, as well as in infections with other enveloped viruses.
No takes yet. Share an insight, caveat, or question.
Vilhelmova et al. (2022) studied Viral infections (HSV-1, PV1, CVB1). Lycium barbarum fruit extract and methylxanthines from Pu-erh and Bancha tea leaves vs. Untreated control was evaluated on Virucidal activity and viral adsorption inhibition. Lycium barbarum fruit extract and methylxanthines from Pu-erh and Bancha tea leaves did not affect intracellular viral replication but significantly inhibited extracellular HSV-1 virions and viral adsorption.
Synapse has enriched 10 related papers. Consider them for comparative context: