Key result
The Omicron variant showed the greatest escape from neutralization by post-vaccination sera with a 38-fold reduction compared to the progenitor virus, though booster sera reduced this to a 19-fold reduction.
Why the study?
Emerging SARS-CoV-2 variant lineages exacerbated the COVID-19 pandemic, requiring assessment and ranking of the risk of variants of concern and interest based on their ability to escape vaccine-induced antibodies.
Population
Post-vaccination sera
Comparison
SARS-CoV-2 variants of concern and interest vs vaccine-induced antibodies
Design
In vitro neutralization study
Authors
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Antibody escape data may guide variant surveillance; leaves open real-world impact on vaccine effectiveness.
Effect estimate: 38-fold reduction
COVID-19 mRNA vaccine booster doses elicit moderate neutralizing activity against the highly evasive Omicron variant, supporting the use of booster vaccination.
Wang et al. (2021) studied SARS-CoV-2. SARS-CoV-2 variants (Omicron) vs. Progenitor 614D reference virus was evaluated on Neutralization titer (FRNT50) fold reduction (38-fold reduction). The Omicron variant showed the greatest escape from neutralization by post-vaccination sera with a 38-fold reduction compared to the progenitor virus, though booster sera reduced this to a 19-fold reduction.
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