Key result
Major abdominal surgery elicited higher serum alarmin levels (except HMGB1) than nonsurgical controls, with S100A8 levels significantly higher in upper gastrointestinal tract surgery (p<0.01).
Why the study?
Does major abdominal surgery increase serum levels of alarmins compared to a nonsurgical group?
Observational (n=117)
Does major abdominal surgery increase serum levels of alarmins compared to a nonsurgical group?
Major abdominal surgery elicits an increase in alarmin levels, with S100A8 serving as a potential biomarker of surgical injury, particularly in upper gastrointestinal tract surgery.
Answers are grounded in this paper and cite their sources.
S100A8 rise after major abdominal surgery may mark upper-GI injury severity; leaves open biomarker utility pending prospective trials.
The dysregulation of inflammatory response to surgical injury affects outcomes. Alarmins, the earliest bioactive substances from damaged cells, play a crucial role in initiating the inflammation. We analyzed serum levels of alarmins (S100A8, S100A12, high mobility group box, and heat shock protein 70) after major abdominal surgery (MAS) in surgical (S) (n = 82) and nonsurgical (NS) groups (n = 35). The main objective was determining a role of selected alarmins in host response to MAS. The secondary objectives were (i) evaluation of the relationship among alarmins and selected biomarkers (C-reactive protein, interleukin-6), (ii) influence of the place of gastrointestinal resection, and (iii) role of alarmins in MAS for cancer. Except for HMGB1, the levels of all alarmins were higher in the S group compared with the NS group. In the S group, positive correlations were found between S100A8 and both IL-6 and CRP. Additionally, the S100A8 level was higher (p < 0.01) in patients who underwent upper gastrointestinal tract (GIT) surgery compared to middle and lower GIT resections. Alarmins levels did not differ between cancer and noncancer patients. MAS is able to elicit increase in alarmin levels. S100A8 can be considered a potential biomarker of surgical injury, especially in the upper part of the GIT.
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Máca et al. (2018) conducted an observational in Major abdominal surgery (n=117). Major abdominal surgery vs. Nonsurgical controls was evaluated on Serum levels of alarmins (S100A8, S100A12, HMGB1, and HSP70). Major abdominal surgery elicited higher serum alarmin levels (except HMGB1) than nonsurgical controls, with S100A8 levels significantly higher in upper gastrointestinal tract surgery (p<0.01).
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