Key result
Long-term follow-up of Roux-en-Y gastric bypass revealed a continued loss of lean soft tissue (4.4 kg decrease from 1 to 9 years post-surgery, P=0.03) correlated with reduced handgrip strength.
Why the study?
Does Roux-en-Y gastric bypass surgery lead to long-term changes in body composition and handgrip strength in women?
Cohort (n=5)
Does Roux-en-Y gastric bypass surgery lead to long-term changes in body composition and handgrip strength in women?
Mean Difference: -4.4
p-value: p=0.03
Long-term follow-up after Roux-en-Y gastric bypass reveals a concerning continued loss of lean mass and functional strength alongside a trend toward fat mass regain.
BACKGROUND: Although most individuals experience successful weight loss following Roux-en-Y gastric bypass (RYGB), weight regain is a concern, the composition of which is not well documented. Our aim was to evaluate changes in body composition and handgrip strength as a measure of functional status in participants from a previous 1-year post-RYGB longitudinal study who had undergone RYGB approximately 9 years prior. METHODS: Five women from an original larger cohort were monitored pre-RYGB and 1.5 months, 6 months, 1 year, and 9 years post-RYGB. Body composition was assessed at all time points using dual energy x-ray absorptiometry and multiple dilution. Handgrip strength was measured using a digital isokinetic hand dynamometer (Takei Scientific Instruments, Ltd, Tokyo, Japan). RESULTS: Mean time to final follow-up was 8.7 years. Lean soft tissue (LST) loss over the ~9-year period was on average 11.9 ± 5.6 kg. Compared with 1-year post-RYGB, 9-year LST was 4.4 ± 3.0 kg lower ( P = .03). Fat-free mass decreased over the 9-year period by 12.6 ± 5.8 kg. Mean fat mass (FM) decreased from 75.4 ± 22.6 kg pre-RYGB to 35.5 ± 21.5 kg 1 year post-RYGB but then trended toward an increase of 8.6 ± 7.0 kg between 1 year and 9 years post-RYGB ( P = .053). Loss of LST was correlated with loss of handgrip strength ( r = 0.64, P = .0005). CONCLUSION: The continued loss of lean mass associated with decreased handgrip strength occurring with long-term trend toward FM regain post-RYGB is concerning. The loss of LST and functional strength carries particular implications for the aging bariatric population and should be investigated further.
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Cole et al. (2016) conducted a cohort in Post-Roux-en-Y gastric bypass (n=5). Roux-en-Y gastric bypass vs. 1-year post-RYGB baseline was evaluated on Lean soft tissue (LST) change between 1-year and 9-years post-RYGB (4.4 kg decrease, p=0.03). Long-term follow-up of Roux-en-Y gastric bypass revealed a continued loss of lean soft tissue (4.4 kg decrease from 1 to 9 years post-surgery, P=0.03) correlated with reduced handgrip strength.
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