Key result
The presence of OSAS in COPD patients was associated with higher sympathetic modulation during RSA-m (P=0.00) and lower parasympathetic modulation during APM (P=0.02) compared to COPD alone.
Why the study?
Does the presence of OSAS in COPD patients impact cardiac autonomic modulation and functional capacity?
Cross-Sectional (n=24)
Does the presence of OSAS in COPD patients impact cardiac autonomic modulation and functional capacity?
The presence of OSAS in COPD patients is associated with marked sympathetic modulation and negatively impacts functional capacity regardless of lung disease severity.
Answers are grounded in this paper and cite their sources.
OSAS may disrupt autonomic balance in COPD; leaves open whether screening or interventions improve outcomes.
Background: The study was conducted to determine the impact of chronic obstructive pulmonary disease (COPD) in association with obstructive sleep apnea syndrome (OSAS) on cardiac autonomic control and functional capacity. Subjects and methods: The study was a cross-sectional prospective controlled clinical study. Heart rate variability indices of 24 COPD (n = 12) and COPD+OSAS (n = 12) patients were evaluated and compared by electrocardiographic recordings acquired during rest, active postural maneuver (APM), respiratory sinus arrhythmia maneuver (RSA-m), and the 6-minute walk test (6MWT). Results: The COPD group presented higher parasympathetic modulation during APM when compared to the COPD+OSAS group ( P = 0.02). The COPD+OSAS group presented higher sympathetic modulation during RSA-m when compared to the COPD group ( P = 0.00). The performance during 6MWT was similarly impaired in both groups, despite the greater severity of the COPD group. Conclusion: Subjects with COPD+OSAS present marked sympathetic modulation, and the presence of OSAS in COPD subjects has a negative impact on functional capacity regardless of the severity of lung disease.
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Zangrando et al. (2018) conducted a cross-sectional in Chronic obstructive pulmonary disease and obstructive sleep apnea syndrome (n=24). Obstructive sleep apnea syndrome (OSAS) vs. COPD without OSAS was evaluated on Sympathetic modulation during respiratory sinus arrhythmia maneuver (RSA-m) (p=0.00). The presence of OSAS in COPD patients was associated with higher sympathetic modulation during RSA-m (P=0.00) and lower parasympathetic modulation during APM (P=0.02) compared to COPD alone.
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