Why the study?
What are the cardiac manifestations and underlying pathogenesis of myasthenia gravis?
Population
Patients with myasthenia gravis and cardiac involvement
Design
Systematic_review
Key result
In a systematic review of 41 articles on myasthenia gravis, 15% of cases had thymoma, of which 97% had antibodies against striated muscle, with Takotsubo cardiomyopathy being the most common cardiomyopathy.
Authors
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Cardiac monitoring warrants consideration in myasthenia gravis; systematic review leaves open questions on prevalence and screening.
Systematic Review
What are the cardiac manifestations and underlying pathogenesis of myasthenia gravis?
Heart muscle is a target for autoimmune inflammation in myasthenia gravis, presenting as various cardiac manifestations including Takotsubo cardiomyopathy, myocarditis, and arrhythmias.
Shivamurthy et al. (2014) conducted a systematic review in Myasthenia gravis. Anti-striational antibodies and thymoma was evaluated on Cardiac manifestations. In a systematic review of 41 articles on myasthenia gravis, 15% of cases had thymoma, of which 97% had antibodies against striated muscle, with Takotsubo cardiomyopathy being the most common cardiomyopathy.