Key result
An atypical case of alveolar soft-part sarcoma of the tongue presented a diagnostic challenge due to the patient's age, location, and histopathologic characteristics.
Case Report (n=1)
Highlights an atypical presentation of alveolar soft-part sarcoma in the tongue, emphasizing diagnostic challenges.
ASPS recognition aids dermatopathology differentials; leaves open targeted therapy trials in translocation-driven sarcomas.
Alveolar soft-part sarcoma is a rare neoplasm of unknown histogenesis that accounts for less than 1% of all soft-tissue sarcomas. The tumor is highly vascularized with small vascular spaces separating nests of cells, and from cytogenetic point of view, is characterized by chromosome rearrangement der(17)t(X:17)(p11:q25) that results in the ASPL-TFE3 translocation. It can occur at any age, but it is most common between 15 and 35 years of age. The prognosis is poor, despite the relatively slow growth of the tumor. We present here an atypical case of alveolar soft-part sarcoma in which the age of the patient, the location, and the histopathologic characteristics of the lesion represented a diagnostic challenge.
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Alegría‐Landa et al. (2018) conducted a case report in Alveolar soft-part sarcoma of the tongue (n=1). An atypical case of alveolar soft-part sarcoma of the tongue presented a diagnostic challenge due to the patient's age, location, and histopathologic characteristics.
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