Key result
A 39-year-old woman developed acute toxic hepatitis within 8 days of amiodarone administration, with liver enzymes progressively returning to normal after drug withdrawal.
Case Report (n=1)
No
Amiodarone can cause acute, potentially fatal toxic hepatitis even in patients without underlying liver disease, necessitating careful monitoring of liver function during administration.
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Amiodarone may cause rapid acute hepatitis even without prior liver disease; this case extends hepatotoxicity reports but remains hypothesis-generating.
Although amiodarone is a widely used and effective long-term antiarrhythmic drug, it is known to have life-threatening adverse effects, including acute hepatotoxicity.Although the occurrence of acute hepatotoxicity after amiodarone administration is rare, it can be fatal.However, this phenomenon has not been well studied.Here, we describe a 39 year old woman with atrial fibrillation and supraventricular tachycardia who developed acute toxic hepatitis within 8 days of amiodarone administration at the recommended dosage.The drug was withdrawn and the laboratory findings progressively returned to normal.(Korean J Anesthesiol 2007; 53: 528～31)
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Kim et al. (2008) conducted a case report in Atrial fibrillation and supraventricular tachycardia (n=1). Amiodarone was evaluated on Development of acute toxic hepatitis. A 39-year-old woman developed acute toxic hepatitis within 8 days of amiodarone administration, with liver enzymes progressively returning to normal after drug withdrawal.
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