Key result
Antibodies against recombinant ribosomal P0 protein (aRibP R0) demonstrated the best diagnostic performance for systemic lupus erythematosus, with an area under the curve of 0.7368 and a sensitivity of 22.0% at 99% specificity.
Why the study?
Does the determination of antibodies against ribosomal P proteins improve the diagnosis of systemic lupus erythematosus?
Cross-Sectional (n=479)
No
Does the determination of antibodies against ribosomal P proteins improve the diagnosis of systemic lupus erythematosus?
Effect estimate: AUC 0.7368 (95% CI 0.69-0.79)
p-value: p=<0.0001
The determination of antibodies against ribosomal P proteins, particularly aRibPR0, improves the diagnostic accuracy for systemic lupus erythematosus, especially in patients negative for anti-Sm and anti-dsDNA antibodies.
No takes yet. Share an insight, caveat, or question.
May aid SLE diagnosis in anti-Sm/dsDNA-negative patients; leaves open need for prospective validation before routine use.
Barkhudarova et al. (2011) conducted a cross-sectional in Systemic lupus erythematosus (n=479). Anti-ribosomal P protein antibodies (aRibP R0, R1, R2, NH) vs. Patients with other rheumatic diseases and healthy donors was evaluated on Diagnostic performance (Area Under the Curve) of aRibP R0 for systemic lupus erythematosus (AUC 0.7368, 95% CI 0.69-0.79, p=<0.0001). Antibodies against recombinant ribosomal P0 protein (aRibP R0) demonstrated the best diagnostic performance for systemic lupus erythematosus, with an area under the curve of 0.7368 and a sensitivity of 22.0% at 99% specificity.
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