What question did this study set out to answer?

Investigate polyploid evolution, genomic stability, and ongoing domestication of ale brewing yeast under the selective pressures of serial repitching in commercial breweries.

June 29, 2020Open Access

Genomic stability and adaptation of beer brewing yeasts during serial repitching in the brewery

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Authors

CLChristopher R. L. LargeUniversity of Pennsylvania NHNoah A. HansonUniversity of Washington ATAndreas TsourisUniversity of Freiburg

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Implication

Genomic time-course analysis reveals recurrent aneuploidy and mitotic recombination in serial-repitched ale yeasts, indicating ongoing adaptation and domestication in modern breweries.

Key Points

Investigate polyploid evolution, genomic stability, and ongoing domestication of ale brewing yeast under the selective pressures of serial repitching in commercial breweries.
Generated population time courses from multiple commercial breweries utilizing related ale yeast strains across consecutive beer fermentation cycles.
Applied whole-genome sequencing to track structural genomic rearrangements and allele frequency changes during adaptation to brewing environments.
Identified recurrent structural variations, specifically aneuploidy and mitotic recombination involving particular chromosomes, that consistently rose to detectable frequencies across independent breweries.
Demonstrated that ongoing brewery repitching selects for shared genomic haplotypes, leading to reduced intragenomic diversity and mirroring domestication syndromes observed in agricultural crops.

Cite This Study

Large et al. (2020) studied this question.

synapsesocial.com/papers/6aa0b9be96c8fbb7e31a0453 https://doi.org/10.1101/2020.06.26.166157

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Implication

Genomic time-course analysis reveals recurrent aneuploidy and mitotic recombination in serial-repitched ale yeasts, indicating ongoing adaptation and domestication in modern breweries.

Genomic stability and adaptation of beer brewing yeasts during serial repitching in the brewery

Discussion

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Implication

Key Points

Cite This Study

Genomic stability and adaptation of beer brewing yeasts during serial repitching in the brewery

Discussion

Member takes

Implication

Key Points

Cite This Study

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