What question did this study set out to answer?

To identify and characterize the specific platelet function abnormalities underlying hemorrhagic and thrombotic complications in patients with myeloproliferative disorders.

July 17, 1972JAMA

Abnormalities of platelet function in the myeloproliferative disorders

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Authors

JCJeanette M. CardamoneAgricultural Research Service

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Implication

Cohort study demonstrates universal platelet function abnormalities in myeloproliferative disorders, indicating defective platelets drive clinical bleeding complications.

Key Points

To identify and characterize the specific platelet function abnormalities underlying hemorrhagic and thrombotic complications in patients with myeloproliferative disorders.
Evaluated platelet function in 21 consecutive patients with polycythemia vera, myelogenous leukemia, agnogenic myeloid metaplasia, or erythroleukemia at the University of Minnesota Hospitals.
Assessed platelet activity using both standard tests and sensitive, recently developed functional assays.
Reviewed therapeutic responses in two representative clinical cases to evaluate management strategies for hemorrhagic complications.
All 21 patients (100%) exhibited measurable abnormalities in platelet function.
Functional platelet impairments were notably more severe in individuals who presented with clinically apparent bleeding diatheses.

Cite This Study

Jeanette M. Cardamone (1972) studied this question.

synapsesocial.com/papers/6aa0b9f307a6aa73709d23f9 https://doi.org/10.1001/jama.221.3.270

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Implication

Cohort study demonstrates universal platelet function abnormalities in myeloproliferative disorders, indicating defective platelets drive clinical bleeding complications.

Abnormalities of platelet function in the myeloproliferative disorders

Discussion

Member takes

Implication

Key Points

Cite This Study

Abnormalities of platelet function in the myeloproliferative disorders

Discussion

Member takes

Implication

Key Points

Cite This Study

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